What is VIVITROL?
Opioid and alcohol dependence are chronic, relapsing brain diseases that affect people psychologically and physically. While counseling may help patients work through the psychological aspects of dependence, medication may help address the physical effects in the brain.1
Used with counseling, VIVITROL is a non-addictive, once-monthly injectable medication for treating opioid and alcohol dependence. It is a medication-assisted treatment (MAT) that does not contain opioids.2,3
VIVITROL must be prepared and administered by a healthcare provider.
It is recommended patients stop taking opioids or opioid-containing medications for a minimum of 7–10 days before starting VIVITROL to avoid precipitation of opioid withdrawal that may be severe.
- Monthly extended-release injectable naltrexone
- Opioid antagonist
- Not associated with diversion
- Requires opioid detox
- Part of a comprehensive management program that includes psychosocial support
*VIVITROL is delivered via intramuscular gluteal injection, alternating buttocks for each subsequent injection.
VIVITROL MAY BE RIGHT FOR OPIOID AND ALCOHOL DEPENDENT INDIVIDUALS IN YOUR PROGRAM
VIVITROL is indicated for2:
- Treatment of alcohol dependence in patients who are able to abstain from alcohol in an outpatient setting prior to initiation of treatment with VIVITROL. Patients should not be actively drinking at the time of initial VIVITROL administration.
- Prevention of relapse to opioid dependence, following opioid detoxification.
- VIVITROL should be part of a comprehensive management program that includes psychosocial support.
VIVITROL is contraindicated in patients2:
- Receiving opioid analgesics
- With current physiologic opioid dependence
- In acute opioid withdrawal
- Who have failed the naloxone challenge test or have a positive urine screen for opioids
- Who have exhibited hypersensitivity to naltrexone, polylactide-co-glycolide (PLG), carboxymethylcellulose, or any other components of the diluent
Explore information about how alcohol and opioids affect the brain, and how medication-assisted treatment may help.
HOW VIVITROL WORKS
VIVITROL is an opioid antagonist.2 Learn more about offering VIVITROL and counseling as part of your program.
EFFICACY AND SAFETY
Learn more about the benefits and risks of VIVITROL.
VIVITROL is not right for everyone. There are significant risks from VIVITROL treatment, including but not limited to, risk of opioid overdose, injection site reaction and sudden opioid withdrawal. See Important Safety Information below.
- National Institute on Drug Abuse. Drugs, Brains, and Behavior: the Science of Addiction. NIH publication No. 14-5605.
https://www.drugabuse.gov/sites/default/files/soa_2014.pdf. Revised July 2014. Accessed April 10, 2019.
- VIVITROL [prescribing information]. Waltham, MA: Alkermes, Inc.; rev September 2019.
- Substance Abuse and Mental Health Services Administration. Naltrexone. https://www.samhsa.gov/medication-assisted-treatment/treatment/naltrexone. September 2016. Accessed February 2019.